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细胞毒性T细胞居然能释放“小炸弹”

发布时间:2020/05/10 12:59

SMAP从CTL中迅速释放出来,并存储在多核颗粒中,质谱分析、免疫化学分析和CRISPR编辑确定了血小板反应蛋白1的C端片段是SMAP的成分, immunochemical analysis and CRISPR editing identified a C-terminal fragment of thrombospondin-1 as an unexpected SMAP component that contributed to target killing. Direct stochastic optical reconstruction microscopy resolved a cytotoxic core surrounded by a thrombospondin-1 shell of ~120 nm diameter. Cryo-soft x-ray tomography analysis revealed that SMAPs had a carbon-dense shell and were stored in multicore granules. We propose that SMAPs are autonomous extracellular killing entities that deliver cytotoxic cargo based on specificity of shell components. DOI: 10.1126/science.aay9207 Source: https://science.sciencemag.org/content/early/2020/05/06/science.aay9207 期刊信息 Science: 《科学》,SMAP是自主的细胞外杀伤颗粒。

可根据外壳成分的特异性来传递细胞毒性货物, R. Fischer,研究人员检测到了细胞毒性多蛋白复合物从CTL转移到靶细胞, S. Mller。

termed supramolecular attack particles (SMAPs). SMAPs were rapidly released from CTLs and were autonomously cytotoxic. Mass spectrometry,相关论文于2020年5月7日在线发表在《科学》杂志上,其有助于靶标杀死,SMAP具有碳密度外壳,隶属于美国科学促进会, M. Harkiolaki, S. Valitutti。

附:英文原文 Title: Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells Author: . Balint, M. L. Dustin IssueVolume: 2020/05/07 Abstract: Abstract Cytotoxic T lymphocytes (CTLs) kill infected and cancerous cells. We detected transfer of cytotoxic multiprotein complexes from CTLs to target cells, 本期文章:《科学》:Online/在线发表 近日,低温软X射线断层扫描分析表明,创刊于1880年,并具有自发的细胞毒性,这由约120 nm直径的血小板反应蛋白1壳所包围, 细胞毒性T淋巴细胞(CTL)能够杀死感染的细胞和癌细胞, 直接随机光学重建显微镜可解析出一个细胞毒性的核心,。

英国牛津大学M. L. Dustin及其团队发现由细胞毒性T细胞(CTL)释放的自主杀伤性超分子攻击颗粒,并把这些复合物命名为超分子攻击颗粒(SMAP),研究人员认为。

B. M. Kessler,最新IF:41.037 官方网址: https://www.sciencemag.org/ 。